Observational analysis identified distinct cytokine profiles in ulcerative colitis patients in deep remission, highlighting potential therapeutic responses.
Background: Ulcerative colitis (UC) is a chronic relapsing-remitting disease characterized by distinct molecular patterns and proinflammatory pathways. Through advances in therapy and monitoring-strategies, long lasting remission can be achieved in an increasing number of patients. Our aim was to investigate cytokine signatures in the interstitial microenvironment at protein and RNA level in UC patients showing deep remission (DR) to better understand the response to existing therapies. We hypothesize that the DR forms a distinct group that differs in its local intestinal cytokine profile from mild activity and non-IBD controls.
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Gluschke et al. (2025) studied this question.
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