What question did this study set out to answer?

This study aims to understand how disease duration affects metabolic and lipidomic changes in ulcerative colitis, particularly during remission.

May 24, 2026BMC GastroenterologyOpen Access

Plasma metabolomic and lipidomic profiling reveals distinct molecular signatures and time-dependent remodeling in ulcerative colitis

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Randomized trial examines metabolic and lipidomic alterations in ulcerative colitis during remission, indicating ongoing molecular changes.

This study aims to understand how disease duration affects metabolic and lipidomic changes in ulcerative colitis, particularly during remission.
Analyzed plasma samples from 58 UC patients in remission and 70 healthy controls using GC–MS and LC–MS.
Patients stratified by disease duration (≤ 2 years vs. > 2 years).
Applied multivariate and univariate analyses, including PLS-DA and VIP scoring.
UC patients exhibited significantly altered plasma profiles with 15 metabolites and 126 lipid species affected.
Notable disruptions in pyruvic and lactic acid levels, indicating impaired energy and redox homeostasis.
Lipidomic profiling identified disturbances across various lipid classes, revealing persistent oxidative and inflammatory imbalances.

Bilican et al. (2026) studied this question.

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Randomized trial examines metabolic and lipidomic alterations in ulcerative colitis during remission, indicating ongoing molecular changes.