What question did this study set out to answer?

To investigate the influence of disease duration on metabolic and lipidomic changes in ulcerative colitis patients.

P0555Plasma Metabolomic and Lipidomic Profiling Reveals Distinct Molecular Signatures and Time-Dependent Remodeling in Ulcerative Colitis

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Examines metabolic and lipid changes in ulcerative colitis, indicating ongoing biological activity during remission.

To investigate the influence of disease duration on metabolic and lipidomic changes in ulcerative colitis patients.
Analyzed plasma samples from ulcerative colitis patients and healthy controls using GC-MS and LC-MS.
Stratified patients by disease duration (≤2 years vs >2 years).
Employed multivariate and univariate statistical analyses including PLS-DA and t-tests.
Conducted pathway enrichment analysis using the KEGG database.
Identified 140 metabolites, with significant differences in 15 metabolites between the groups.
Observed distinct metabolic patterns based on disease duration, with specific alterations in amino acids and lipids.
Higher levels of certain amino acids were linked to early disease, while longer duration correlated with increased sphingomyelins and triglycerides.
Pathway analysis revealed persistent biological activity related to various metabolic processes.

Bilican et al. (2026) studied this question.

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