What question did this study set out to answer?

This study aims to characterize ulcerative colitis patients whose disease extent regresses and determine the time to regression.

P0570A Distinct Disease Course: Clinical Predictors and Reduced Inflammatory Burden in UC Patients with Extent Regression

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Retrospective study identifies clinical predictors of disease regression in ulcerative colitis, suggesting a less aggressive trajectory.

This study aims to characterize ulcerative colitis patients whose disease extent regresses and determine the time to regression.
Conducted a retrospective study at University Hospital Reina Sofía.
Defined regression according to the Montreal classification in patients with left-sided or extensive colitis.
Used logistic regression to identify predictors of regression.
Applied Cox regression to evaluate the time to regression and quantify inflammatory burden using AUC/year for fecal calprotectin and C-reactive protein.
Out of 538 patients, 93 (17.3%) showed disease regression after a median follow-up of 14.5 years.
Median time to regression was 8.7 years.
Younger age, extensive colitis, and extraintestinal manifestations were identified as predictors of regression.
Patients with regression exhibited significantly lower long-term inflammatory burdens, indicating a milder inflammatory phenotype.

Gros et al. (2026) studied this question.

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