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To evaluate the frequency and risk factors associated with proximal extension in distal ulcerative colitis.

P0264Proximal Diseaase Extension and Associated Risk Factors in Patients with Distal Ulcerative Colitis

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To evaluate the frequency and risk factors associated with proximal extension in distal ulcerative colitis.
Retrospective analysis of patients with proctitis/proctosigmoiditis or left-sided colitis from 1999 to 2024.
Demographic and clinical data extracted from patient files and electronic records.
Proximal extension defined as progression beyond the splenic flexure.
Statistical analyses performed using univariate and multivariate methods.
26.6% of patients progressed to extensive colitis over a median follow-up of 9 years.
Younger patients (median age 30) were more likely to progress than older ones (median age 40).
Left-sided colitis (39.3% progression) showed higher rates than proctitis/proctosigmoiditis (18.7%).
Patients requiring systemic steroids (37.5%) progressed more frequently than those who did not (14.4%).
Multivariate analysis identified age <40, left-sided colitis, and systemic steroid use as independent predictors of progression.

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Analysis reveals risk factors for proximal extension in distal ulcerative colitis, suggesting better monitoring strategies.

Adin et al. (2026) studied this question.

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