What question did this study set out to answer?

The study aims to understand redox alterations in ulcerative colitis by profiling related metabolites.

P0035Integrated profiling of the extracellular thiol redox metabolome reveals reductive stress in Ulcerative Colitis

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Exploratory study investigates redox alterations in ulcerative colitis, suggesting shifts in oxidative balance.

The study aims to understand redox alterations in ulcerative colitis by profiling related metabolites.
Plasma samples collected from patients with active and quiescent UC and healthy controls.
Glutathione, cysteine, and sulfide levels quantified using UHPLC-MS/MS.
Principal component analysis used to identify biomarker patterns among groups.
ROC analyses conducted to distinguish between active and quiescent UC.
Active UC shows significant redox-related metabolite disruptions compared to quiescent UC and healthy controls.
Elevated GSH/GSSG and Cys/CySS ratios observed in quiescent and active UC.
Homocysteine levels significantly increased in active UC.
PCA revealed clear separation among healthy controls, quiescent, and active UC.

Geertsema et al. (2026) studied this question.

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