What question did this study set out to answer?

The aim is to explore how plasma immune profiles differ between Crohn's disease and ulcerative colitis and their relation to disease characteristics.

January 23, 2026Journal of Crohn s and Colitis

P0118Plasma proteomic signatures relate to disease course and intestinal immune responses, uncovering immunotypes among Crohn’s Disease and Ulcerative Colitis patients

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Authors

BCB CaladoErasmus MC MHMaud HerediaErasmus MC MCMohammed CharroutDelft University of Technology

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Implication

Research demonstrates distinct immune profiles related to disease course in Crohn's Disease and Ulcerative Colitis patients, suggesting paths for personalized treatment.

Key Points

The aim is to explore how plasma immune profiles differ between Crohn's disease and ulcerative colitis and their relation to disease characteristics.
Analyzed plasma immune proteins in therapy-naïve pediatric Crohn’s Disease and Ulcerative Colitis patients.
Measured 92 plasma immune proteins, circulating T helper cell subpopulations, and intestinal permeability.
Grouped patients based on immune profiles and assessed clinical parameters.
27 proteins distinguished Crohn’s Disease patients from healthy controls, identifying distinct immunity clusters.
Crohn's high-activity patients showed increased immune pathway proteins and higher intestinal permeability.
In Ulcerative Colitis, 23 proteins indicated increased intestinal disease extent and severity, requiring earlier treatment.

Cite This Study

Calado et al. (2026) studied this question.

synapsesocial.com/papers/69730fe2c8125b09b0d1f9bd https://doi.org/10.1093/ecco-jcc/jjaf231.299

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Implication

Research demonstrates distinct immune profiles related to disease course in Crohn's Disease and Ulcerative Colitis patients, suggesting paths for personalized treatment.

P0118Plasma proteomic signatures relate to disease course and intestinal immune responses, uncovering immunotypes among Crohn’s Disease and Ulcerative Colitis patients

Discussion

Member takes

Implication

Key Points

Cite This Study

P0118Plasma proteomic signatures relate to disease course and intestinal immune responses, uncovering immunotypes among Crohn’s Disease and Ulcerative Colitis patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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