What question did this study set out to answer?

The research aims to explore the relationship between circulating inflammatory proteins and the risk of disease progression in inflammatory bowel disease.

January 23, 2026Journal of Crohn s and Colitis

DOP065Circulating inflammatory proteins as prognostic biomarkers for disease progression in Inflammatory Bowel Disease

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Authors

FVF VeenstraUniversity Medical Center Groningen ZRZ M Al RadiUniversity Medical Center Groningen SGSem GeertsemaUniversity Medical Center Groningen

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Implication

Investigation shows associations between inflammatory proteins and disease progression in IBD, suggesting a potential for earlier interventions.

Key Points

The research aims to explore the relationship between circulating inflammatory proteins and the risk of disease progression in inflammatory bowel disease.
Measured 83 inflammation-related plasma proteins in 996 patients using proximity extension assay technology.
Defined disease progression as the need for IBD-related surgery or progressive stenosis in Crohn’s disease.
Utilized Cox proportional hazards regression for association analysis with multiple testing correction.
Performed subgroup analyses based on disease activity and location.
33.7% of patients with Crohn’s disease and 10.7% with ulcerative colitis experienced disease progression over a median follow-up of 9.5 years.
21 proteins were significantly associated with disease progression in Crohn’s disease, and 10 proteins in ulcerative colitis.
Four key proteins in Crohn’s disease linked to progression included Delta and Notch-like receptor, interferon gamma, interleukin-17 A, and macrophage colony stimulating factor 1.
In ulcerative colitis, significant proteins included CXCL9, CXCL11, interleukin-8, and interleukin-10.

Cite This Study

Veenstra et al. (2026) studied this question.

synapsesocial.com/papers/69730f9fc8125b09b0d1f5fb https://doi.org/10.1093/ecco-jcc/jjaf231.102

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Implication

Investigation shows associations between inflammatory proteins and disease progression in IBD, suggesting a potential for earlier interventions.

DOP065Circulating inflammatory proteins as prognostic biomarkers for disease progression in Inflammatory Bowel Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

DOP065Circulating inflammatory proteins as prognostic biomarkers for disease progression in Inflammatory Bowel Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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