What question did this study set out to answer?

The aim is to define systemic antibody responses linked to disease progression in inflammatory bowel disease.

DOP013Systemic antibody responses against herpesviruses and Bacteroides associate with disease progression in Inflammatory Bowel Disease

View Full Paper

Ask AI

Bookmark

Authors

Identifies immune signatures associated with disease progression in inflammatory bowel disease, highlighting prognostic implications.

The aim is to define systemic antibody responses linked to disease progression in inflammatory bowel disease.
Analyzed serum samples from 416 patients in the 1000IBD cohort.
Defined disease progression as the need for IBD-related surgery or development of intestinal stenosis.
Utilized phage-display immunoprecipitation sequencing to assess antibody repertoires against 344,000 antigens.
Conducted multivariable Cox regression analyses to examine associations between antibody responses and progression risk.
24% of patients experienced disease progression during a median follow-up of approximately 11 years.
In Crohn's disease, patients showed overrepresented antibody responses against Bacteroides and Streptococcus, while responses against herpesviruses were underrepresented.
In ulcerative colitis, antibody responses predominantly targeted cytomegalovirus, with decreased responses to Epstein–Barr virus and Bacteroides.

Griesbaum et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark