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The research aims to characterize preclinical immunological alterations in inflammatory bowel disease through serum antibody profiling.

July 23, 2026Gut

Deciphering the prodrome of inflammatory bowel disease up to 10 years before disease onset by massively parallel serology

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Randomized trial identifies preclinical immune changes in inflammatory bowel disease, suggesting early detection possibilities.

The research aims to characterize preclinical immunological alterations in inflammatory bowel disease through serum antibody profiling.
Applied phage-display immunoprecipitation sequencing to profile antibody responses in 2000 serum samples from 500 individuals with IBD and healthy controls.
Longitudinal samples were collected up to 10 years before diagnosis from a military cohort.
Assessed responses against 357,000 diverse peptides linked to various disease-associated factors.
Increased antibody variability was noted up to 4 years before diagnosis in individuals developing Crohn's or ulcerative colitis.
Elevated responses to herpesvirus (especially Epstein-Barr virus) and anti-flagellin antibodies were observed up to 10 years prediagnosis in Crohn’s disease.
Pre-ulcerative colitis displayed a signature of combined antimicrobial and autoantibody responses, suggesting distinct immune profiles.

Bourgonje et al. (2026) studied this question.

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