What question did this study set out to answer?

Investigate the role of IL-18 in modulating Thm17 responses in pediatric inflammatory bowel disease (IBD).

DOP019IL-18 as an enhancer of the pathogenic memory Th1/Th17 phenotype in pediatric Inflammatory Bowel Disease

View Full Paper

Ask AI

Bookmark

Authors

Observational study shows IL-18 correlates with inflammatory markers in pediatric IBD, indicating its role in disease severity.

Investigate the role of IL-18 in modulating Thm17 responses in pediatric inflammatory bowel disease (IBD).
Analyzed plasma proteomics and intestinal biopsy transcriptomes from therapy-naïve pediatric CD and UC patients.
Examined correlations between IL-18 levels and Th1/Th17 cell markers in plasma.
Assessed IL-18 receptor expression and cytokine responses in vitro using flow cytometry.
Plasma IL-18 levels correlated with Th1-like proteins in both CD and UC.
In CD, higher IL-18 levels were related to worse clinical scores and more ex-Thm17 cells.
Activated Thm cells showed increased IL-18 receptor expression and Th17-like cell frequencies when stimulated with IL-12.

Grillmaier et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark