What question did this study set out to answer?

To characterize the role of immune checkpoints in T-cell phenotypes in ulcerative colitis, especially during active disease.

P0113Activated PD-1+TIGIT+ T-Cells Define a Tissue-Specific Immune Signature in Active Ulcerative Colitis

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To characterize the role of immune checkpoints in T-cell phenotypes in ulcerative colitis, especially during active disease.
Collected paired blood and intestinal samples from patients with active and quiescent ulcerative colitis and controls.
Isolated peripheral blood mononuclear cells and lamina propria mononuclear cells.
Used high-dimensional spectral flow cytometry to profile T-cell subsets and activation/checkpoint markers.
Conducted statistical comparisons using Kruskal–Wallis tests.
Identified a unique T-cell subset (PD-1+TIGIT+HLA-DR+CD25+) enriched in the inflamed mucosa of active UC.
Observed depletion of memory T cells in blood, with expansions in the mucosa indicative of active migration.
Noted that this T-cell subset was absent in controls and patients with quiescent UC, emphasizing its specificity to active disease.

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This analysis reveals a unique immune signature in active ulcerative colitis, suggesting potential biomarkers and treatment targets.

Castillo et al. (2026) studied this question.

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