High expression of BMP-9 in colorectal cancer (CRC) is associated with a better patients’ prognosis

Ting Jiang; D Rana-Seyfert; H Gaitantzi; Christoph Reißfelder; Katja Breitkopf‐Heinlein

doi:10.1055/s-0045-1810925

September 1, 2025Zeitschrift für Gastroenterologie

High expression of BMP-9 in colorectal cancer (CRC) is associated with a better patients’ prognosis

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Key Points

Higher expression of bmp-9 correlates with improved prognosis in colorectal cancer patients, indicating beneficial effects.
Patients with elevated bmp-9 show better outcomes, reinforcing its potential protective roles, particularly through id1.
This research utilized observational analysis to explore the relationship between bmp-9 expression and patient prognosis in crc.
Understanding bmp-9’s role in crc may lead to novel therapeutic strategies and improve clinical outcomes for patients.

Implication

Analysis reveals that high bmp-9 levels improve prognosis in crc patients, suggesting protective roles of id1.

Abstract

BMP-9 is a secreted cytokine belonging to the TGF-β superfamily and circulating with the blood stream of healthy individuals in a constitutive fashion. We previously showed that in addition to the liver, BMP-9 is also locally expressed in the small intestine and by upregulating ID1 expression, it seems to have protective functions in the setting of colorectal cancer (CRC).

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Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68c193fb9b7b07f3a06184df https://doi.org/10.1055/s-0045-1810925

View Full Paper

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High expression of BMP-9 in colorectal cancer (CRC) is associated with a better patients’ prognosis

Key Points

Implication

Abstract

Discussion

Cite This Study

High expression of BMP-9 in colorectal cancer (CRC) is associated with a better patients’ prognosis

Key Points

Implication

Abstract

Discussion

Cite This Study

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