Observational analysis shows higher ALK1 levels correlate with improved prognosis in HCC patients, suggesting BMP-9 plays a pivotal role.
BMP-9, a hepatic cytokine belonging to the TGF-β superfamily, has gathered attention in recent studies due to its controversial role in cancer, including hepatocellular carcinoma (HCC). Some investigations indicate BMP-9's promotion of cell proliferation and epithelial-to-mesenchymal transition (EMT), while others suggest anti-proliferative effects and a reduction in mesenchymal markers in HCC cells. The aim of this study was therefore to better understand BMP-9/ALK1 signaling in HCC.
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Breitkopf‐Heinlein et al. (2025) studied this question.
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