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September 10, 2025BioResourcesOpen Access

Suppression of NF κB p65 and STAT3 by Melicope pteleifolia extract mitigates ovalbumin driven allergic rhinitis in mice

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Authors

AZAling ZhangJJJialiu JiJWJiani Wu

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Overview

Observational analysis shows that melicope pteleifolia significantly suppresses NF kappa b and STAT3 in allergic rhinitis, indicating its potential as a non-steroidal therapy.

Key Points

  • Melicope pteleifolia effectively alleviates nasal symptoms in allergic rhinitis, with effects similar to dexamethasone.
  • Treatment with melicope pteleifolia led to significant reductions in eosinophils, neutrophils, and macrophages in nasal lavage fluid.
  • Histological examination revealed the restoration of nasal-associated lymphoid tissue with melicope pteleifolia treatment.
  • Suppression of nf kappa b p65 and inhibition of stat3 signaling by melicope pteleifolia highlights its anti-inflammatory action.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c194029b7b07f3a0618655https://doi.org/10.15376/biores.20.4.9296-9311
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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  5. 5Immunomodulation in allergic rhinitis: Insights from Th2 cells and NLRP3/IL‐18 pathway2024 · 20 citations