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September 10, 2025Inflammatory Bowel DiseasesOpen Access

Patient-Specific Regulatory Network Rewiring in Inflammatory Bowel Disease: How Genetic Polymorphisms Divert Incoming Signals and Contribute to Disease Pathogenesis

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Authors

BBBalázs BohárJTJohn P. ThomasYLYufan Liu

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Overview

Observational analysis shows gene expression changes in IBD patients, indicating regulatory network shifts due to SNPs.

Key Points

  • The study reveals that genetic polymorphisms rearrange gene regulatory networks in inflammatory bowel disease patients, leading to altered gene expression.
  • Analysis of genotype data from 2636 IBD patients showed distinct changes in transcription factor binding due to non-coding SNPs.
  • The method utilized a systems genomics pipeline to analyze SNP effects on upstream signaling pathways, highlighting the complexity of IBD.
  • Understanding these regulatory shifts is essential for grasping disease mechanisms and personalizing treatment strategies for IBD patients.

Cite This Study

Bohár et al. (2025) studied this question.

synapsesocial.com/papers/68c194029b7b07f3a06187a8https://doi.org/10.1093/ibd/izaf173
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  4. 4Predicting the effects of SNPs on transcription factor binding affinity2019 · 72 citations
  5. 5Th17 Cells in Inflammatory Bowel Disease: Cytokines, Plasticity, and Therapies2021 · 124 citations