What does this research mean for the field?

Specific single nucleotide polymorphisms (SNPs), including the H63D variant and 3' UTR SNPs affecting miRNA binding, are pivotal markers that influence therapy response and hold clinical potential for personalized treatment in inflammatory bowel disease. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to explore how specific genetic variations (SNPs) influence treatment responses in inflammatory bowel disease (IBD) patients.

May 17, 2026

Unraveling genetic signatures: the impact of SNPs on therapy response in inflammatory bowel disease patients.

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Authors

NKNesa KazemifardShahid Beheshti University of Medical Sciences MAMasomeh AskariShahid Beheshti University of Medical Sciences LNLeila NavapourShiraz University

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Implication

Systematic review identifies SNPs affecting drug response in inflammatory bowel disease, suggesting precision medicine implications.

Key Points

This research aims to explore how specific genetic variations (SNPs) influence treatment responses in inflammatory bowel disease (IBD) patients.
Conducted a systematic literature review to identify relevant genes affecting drug response in IBD.
Performed SNP detection and filtered SNPs based on population frequencies using global databases.
Analyzed functional impacts of missense variants and evaluated gene expression through molecular dynamics and RNA-seq data.
Identified the H63D SNP variant suggesting it disrupts normal function.
Highlighted SNPs as crucial markers for personalized treatment strategies in IBD.
Emphasized the need for experimental validation to enhance therapeutic outcomes.

Cite This Study

Kazemifard et al. (2025) studied this question.

synapsesocial.com/papers/6a095c037880e6d24efe1ee7 https://doi.org/10.22037/ghfbb.v18i4.3174

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Unraveling genetic signatures: the impact of SNPs on therapy response in inflammatory bowel disease patients.

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Implication

Key Points

Cite This Study

Unraveling genetic signatures: the impact of SNPs on therapy response in inflammatory bowel disease patients.

Discussion

Member takes

Implication

Key Points

Cite This Study

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