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September 10, 2025JOR SpineOpen Access

A Cross‐Tissue Transcriptome‐Wide Association Study Identified Susceptibility Genes for Intervertebral Disc Degeneration

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Authors

LZLi ZhangWZWen Xiang ZhaoHYHongsheng Yang

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Overview

Cross-tissue analysis reveals six susceptibility genes for intervertebral disc degeneration, indicating potential genetic pathways involved.

Key Points

  • Six susceptibility genes linked to intervertebral disc degeneration were identified through transcriptome analysis.
  • The analysis uncovered 33 genes before narrowing down to six key candidates using genetic methodologies.
  • This approach involved a transcriptome-wide association study along with pathway analysis for comprehensive insights.
  • Findings highlight the genetic factors influencing intervertebral disc degeneration, directing future research on potential therapies.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c194029b7b07f3a0618925https://doi.org/10.1002/jsp2.70109
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification and validation of novel risk genes for intervertebral disc disorder by integrating large-scale multi-omics analyses and experimental studies2025
  2. 2Identification of core genes in intervertebral disc degeneration using bioinformatics and machine learning algorithms2024 · 14 citations
  3. 3Unveiling key genes for intervertebral disc degeneration prediction and potential drug discovery2025
  4. 4Identifying druggable gene-related biomarkers in intervertebral disc degeneration through transcriptome sequencing and mendelian randomization analysis2026
  5. 5GWAS-Informed Candidate Genetic Variants and Gene–Gene/Gene–Environment Interaction Patterns Associated with Intervertebral Disc Degeneration: A Chinese Han Case–Control Study2026