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January 25, 2026

Identifying druggable gene-related biomarkers in intervertebral disc degeneration through transcriptome sequencing and mendelian randomization analysis

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Authors

KWKeping WangLanzhou University Second HospitalKWKeping WangLanzhou University Second HospitalZWZuolong Wu

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Overview

Mendelian randomization analysis reveals biomarkers for intervertebral disc degeneration, suggesting potential for targeted therapy.

Key Points

  • This research aims to identify druggable gene-related biomarkers linked to intervertebral disc degeneration (IDD) and elucidate their roles in the condition.
  • Merged three GEO datasets and a blood-based dataset for analysis.
  • Identified potential druggable genes (PDGs) by intersecting with differentially expressed genes (DEGs).
  • Conducted functional enrichment and immune infiltration analyses.
  • Developed a Lasso regression model for diagnostic purposes and performed Mendelian Randomization analysis to infer causal relationships.
  • Identified fourteen differentially expressed PDGs mainly involved in immune responses and neutrophil activity.
  • Constructed a five-gene diagnostic model demonstrating high accuracy.
  • Confirmed causal links between BPI and CTSG with IDD through Mendelian randomization analysis.
  • BPI negatively associated with oxidative phosphorylation, while CTSG linked to the G2M checkpoint.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6975b2eafeba4585c2d6e686https://doi.org/10.3389/fgene.2026.1627091
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of Biomarkers in Intervertebral Disc Degeneration Using Bioinformatics and Machine Learning Algorithms2024
  2. 2Identification of core genes in intervertebral disc degeneration using bioinformatics and machine learning algorithms2024 · 14 citations
  3. 3Identification and validation of novel risk genes for intervertebral disc disorder by integrating large-scale multi-omics analyses and experimental studies2025
  4. 4Unveiling key genes for intervertebral disc degeneration prediction and potential drug discovery2025
  5. 5Identification and experimental validation of aging-related biomarkers in intervertebral disc degeneration2026