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One fecal pellet to rule them all

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Observational analysis shows data inconsistencies in rodent-based studies due to SPF microbiota, suggesting better models are needed.

Microbiota variability significantly affects reproducibility in rodent-based biomedical studies, leading to inconsistencies.
Emerging evidence highlights the inadequacy of current SPF microbiota to reflect interactions in free-living mammals.
Standardization efforts have failed to create complex and resilient microbial consortia suitable for model organisms.
This signals a need for reevaluating rodent models in research, given their impact on data reliability.

Runge et al. (2025) studied this question.

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