What question did this study set out to answer?

The aim is to highlight the importance of microbial exposure in shaping mammalian physiology and to propose a more natural rodent model.

March 31, 2026Trends in MicrobiologyOpen Access

Game of microbes: a wildling’s guide

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Wildlings guide improves microbial exposure understanding in biomedical research, suggesting better model accuracy.

The aim is to highlight the importance of microbial exposure in shaping mammalian physiology and to propose a more natural rodent model.
Proposed a four-step guide for establishing a multigenerational wildling colony.
Defined the concepts of 'microbial self' and 'microbial nonself'.
Compared conditions between specific pathogen-free and naturally occurring environments.
Naturalizing rodent models leads to improved immune responses and microbial interactions.
Enhanced comparability between murine and human studies is achieved with a wildling colony.
The guide facilitates understanding the biological link among free-living mammals.

Bruno et al. (2026) studied this question.

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