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September 10, 2025Diseases of the Esophagus

Pathologic Complete Response in Esophageal Squamous Cell Cancer: Do Diverse Neoadjuvant Modalities Predict Prognostic Differences?

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XWXiufeng WeiJilin UniversityXCXiankai ChenChinese Academy of Medical Sciences & Peking Union Medical CollegeXDXiaofeng DuanBeijing University of Posts and Telecommunications

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Overview

Multicenter study reveals that neoadjuvant therapy types affect recurrence risk in esophageal cancer patients, suggesting tailored prognosis strategies.

Key Points

  • Significant variations in survival were observed for esophageal cancer patients with pathological complete response.
  • The analysis identified neoadjuvant therapy modality as an independent predictor of recurrence, impacting prognosis.
  • A dynamic nomogram was developed to estimate risk based on multiple prognostic factors in these patients.
  • Decision curve analysis indicated a superior clinical net benefit of the model compared to traditional AJCC staging.

Cite This Study

Wei et al. (2025) studied this question.

synapsesocial.com/papers/68c195559b7b07f3a0618ec3https://doi.org/10.1093/dote/doaf061.214
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Development of a predictive model for pathological complete response following neoadjuvant immunotherapy and chemotherapy in locally advanced resectable esophageal squamous cell carcinoma2026
  2. 2Incidence and prognostic impact of recurrence in esophageal carcinoma patients achieving complete pathological response after neoadjuvant chemoradiotherapy or perioperative chemotherapy.2026
  3. 3Nomogram for predicting pathologic complete response to neoadjuvant chemoradiotherapy in patients with esophageal squamous cell carcinoma2024 · 5 citations
  4. 4Is complete really complete? Prognostic divergence of pathological complete response after FLOT versus CROSS in esophageal adenocarcinoma2026
  5. 5Dynamic radiological features predict pathological response after neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma2024 · 11 citations