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September 10, 2025Pediatric Hematology/Oncology and ImmunopathologyOpen Access

Results of allogeneic hematopoietic stem cell transplantation from a genoidentical sibling after high-dose treosulfan-based conditioning in children with intermediate-risk acute myeloid leukemia in first clinical and hematological remission

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Authors

ИКИ. И. КалининаЛШЛариса ШелиховаMIM. A. Ilushina

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Overview

Observational analysis shows lower relapse rates in children with intermediate-risk AML after HSCT versus chemotherapy, indicating HSCT's potential advantages.

Key Points

  • HSCT significantly reduced the risk of relapse in children with intermediate-risk AML, with a cumulative incidence of 0.23 ± 0.10.
  • The study involved 22 HSCT recipients achieving engraftment, with a median granulocyte recovery at day +16 and platelet recovery at day +15.
  • High-dose treosulfan conditioning resulted in toxicities like mucositis (54%) and skin lesions (27%), but no toxicity-related mortality.
  • Survival probabilities were 0.88 ± 0.08 for HSCT compared to 0.83 ± 0.03 for chemotherapy, supporting HSCT as an effective treatment.

Cite This Study

Калинина et al. (2025) studied this question.

synapsesocial.com/papers/68c1955c9b7b07f3a06191c8https://doi.org/10.24287/1726-1708-2025-24-2-62-72
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Allogeneic hematopoietic stem cell transplantation outcomes in pediatric patients with refractory acute myeloid leukemia2024
  2. 2Excellent Outcomes of Hematopoietic Stem Cell Transplant for Pediatric High Risk and Relapsed Acute Myeloid Leukemia–A Decade Long Experience From Developing Nation2025
  3. 3Improving outcomes of hematopoietic stem cell transplant for leukemia in children and young adults in resource-limited setting2024 · 4 citations
  4. 4Nonmyeloablative HLA-identical sibling transplant for sickle cell disease in children: A multicenter prospective study2026 · 2 citations
  5. 5Expanding access in pediatrics: Outcomes of haploidentical transplantation with reduced intensity and peripheral blood stem cells2025