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April 10, 2026Blood AdvancesOpen Access

Nonmyeloablative HLA-identical sibling transplant for sickle cell disease in children: A multicenter prospective study

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Authors

RNRobert Sheppard NickelAAAllistair AbrahamKCKuang-Yueh Chiang

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Overview

Multicenter trial evaluates a nonmyeloablative transplant approach in children with sickle cell disease, suggesting a lower toxicity option.

Key Points

  • Evaluate the efficacy and safety of nonmyeloablative HCT in children with sickle cell disease using HLA-identical sibling donors.
  • Conducted a multicenter, prospective clinical trial
  • Included 38 children aged 2.9 to 21.9 years
  • Used alemtuzumab, total body irradiation, and sirolimus for conditioning
  • Monitored engraftment, graft failure, and quality of life outcomes
  • All patients achieved initial engraftment
  • 18.4% experienced secondary graft failure
  • Overall survival at 2 years was 100%
  • Event-free survival was 78.9%
  • Median donor myeloid chimerism was 95%

Cite This Study

Nickel et al. (2026) studied this question.

synapsesocial.com/papers/69d895206c1944d70ce0616dhttps://doi.org/10.1182/bloodadvances.2025019567
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Shifting paradigms from myeloablation to immune modulation: pre-transplant immune-suppression and post-transplant cyclophosphamide in human leucocyte antigen identical related donor hematopoietic stem cell transplantation for sickle cell disease2026
  2. 2Reduced intensity haploidentical bone marrow transplantation in children with severe sickle cell disease (SCD): BMT CTN 15072025 · 4 citations
  3. 3Hematopoietic stem cell transplantation with reduced toxicity myeloablative conditioning regimen for children and adults with sickle cell disease: A brazilian single center experience.2025
  4. 4Encouraging Outcomes of Hematopoeitic Stem Cell Transplantation in Pediatric Sickle Cell Disease- A Decade-Long Experience from the Developing World2025
  5. 5Haploidentical hematopoietic stem cell transplantation in adults with severe sickle cell disease: Long-term outcomes using a modified conditioning regimen with peripheral blood stem cells.2025 · 1 citations