Risk factors and outcomes according to age at transplantation with an HLA-identical sibling for sickle cell disease

Barbara Cappelli; Fernanda Volt; Karina Tozatto‐Maio; Graziana Maria Scigliuolo; Alina Ferster; Sophie Dupont; Belinda Pinto Simões; Amal Al-Seraihy; Mahmoud Aljurf; Fahad Almohareb; Cristina Beléndez; Susanne Matthes; Nathalie Dhédin; Corinne Pondarré; Jean‐Hugues Dalle; Yves Bertrand; Jean Pierre Vannier; Mathieu Kuentz; Patrick Lutz; Gérard Michel; Hanadi Rafii; Bénédicte Neven; Marco Zecca; Peter Bader; Marina Cavazzana; Myriam Labopin; Franco Locatelli; Alessandra Magnani; Annalisa Ruggeri; Vanderson Rocha; Françoise Bernaudin; Josu de la Fuente; Selim Corbacioglu; Éliane Gluckman

doi:10.3324/haematol.2019.216788

Key Points

Evaluate the clinical outcomes and risk factors associated with recipient age in patients undergoing HLA-identical sibling hematopoietic stem cell transplantation for sickle cell disease.
Evaluated outcomes in patients with sickle cell disease receiving allogeneic hematopoietic stem cell transplantation from HLA-identical sibling donors across age categories.
Examined key endpoints including overall survival, event-free survival, regimen-related toxicities, graft rejection, and mortality.
Overall survival (OS) for patients receiving HLA-identical sibling grafts ranges between 91% and 100%.
Event-free survival (EFS) across recipient cohorts ranges from 73% to 100%.

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Implication

Cohort study reveals high survival following sibling stem cell transplantation in sickle cell disease, highlighting the critical influence of recipient age.

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Cappelli et al. (2019) studied this question.

synapsesocial.com/papers/6a731321668da3c6682c1204 https://doi.org/10.3324/haematol.2019.216788

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Risk factors and outcomes according to age at transplantation with an HLA-identical sibling for sickle cell disease

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Risk factors and outcomes according to age at transplantation with an HLA-identical sibling for sickle cell disease

Key Points

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Implication

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