Pharmacotoxicological evaluation of a new original medicinal product for dogs Trazapentine® tablets (succinate trazodone + gabapentin)

The study has established that the absolute (LD100) and median (LD50) lethal doses of the Trazapentin® tablets for dogs cannot be determined. According to the GOST 12.1.007-76 classification, the drug is classified as hazard class IV ‒ slightly hazardous substances. The study of chronic toxicity over a period of 90 days revealed no lethal outcomes or negative effects on the animals’ organisms, both during the administration period and after discontinuation of the Trazapentin®. The absence of allergenic and irritant properties of the drug has been proven.