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September 10, 2025Organic Letters

Asymmetric Total Synthesis of 5,10-seco-Neoansamycin A

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Authors

HXHuacheng XuCZCheng ZouANAdila Nazli

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Overview

This research demonstrates a convergent synthesis approach and highlights the potential anticancer applications of 5,10-seco-neoansamycin A.

Key Points

  • Overall yield of the synthesis was 6.7% over 20 steps, showcasing the efficiency of the approach.
  • The method incorporates late-stage macrolactamization and an asymmetric aldol reaction to enhance synthesis.
  • This synthesis can aid in developing other ansamycin natural products and exploring their anticancer potential.
  • Assignment of the absolute configuration of 5,10-seco-neoansamycin A supports further studies in this area.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68c1956b9b7b07f3a0619ba3https://doi.org/10.1021/acs.orglett.5c02111
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