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Co‐Loaded Nanoparticles of Empagliflozin and Rutin for Pancreatitis Prevention and Anticancer Activity

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Co-loading empagliflozin and rutin in nanoliposomes enhanced anticancer efficacy and modulated oxidative stress.
Empa-Rut NLs reduced IL-1β and increased catalase levels, indicating a positive change in inflammatory response.
Nanoliposomes showed distinct properties, with Empa-NLs having a smaller size and different zeta potential than Empa-Rut NLs.
Encapsulation efficiency was 10.8% for empagliflozin and 66.92% for rutin, highlighting significant differences in drug loading.

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The study demonstrates improved anticancer activity and antioxidant effects in co-loaded nanoparticle formulations, suggesting novel therapy options.

Maan et al. (2025) studied this question.

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The study demonstrates improved anticancer activity and antioxidant effects in co-loaded nanoparticle formulations, suggesting novel therapy options.