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September 10, 2025Advanced Pharmaceutical BulletinOpen Access

Codelivery of Raloxifene and Rutin as PEGylated Nanoliposomes: Formulation, Characterization, and Prophylactic Activity Against Breast Cancer

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Authors

MOMaryam Abdulmaged OleiwiAAAli Al‐SamydaiAAAya Y. Al‐Kabariti

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Overview

Experiment shows enhanced encapsulation efficiency and reduced cytotoxicity in breast cancer cells, highlighting new treatment potential.

Key Points

  • Encapsulation efficiency reached 91.28% for raloxifene and 78.12% for rutin in nanoliposomes, showcasing effective delivery methods.
  • Stability of PEGylated nanoliposomes lasted two months at room temperature, indicating long-term feasibility as a treatment.
  • MTT assays reveal that nanoliposomes mitigate cytotoxicity against breast cancer cells while enhancing safety in normal cells.
  • Biphasic release patterns suggest controlled release, enhancing the opportunity for targeted delivery of therapeutic compounds.

Cite This Study

Oleiwi et al. (2025) studied this question.

synapsesocial.com/papers/68c1a5eb54b1d3bfb60df67bhttps://doi.org/10.34172/apb.025.43681
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Preparation and Characterization of Raloxifene- and Rutin-Co-loaded Chitosan Nanoparticles for the Treatment of Colon Cancer2026
  2. 2Raloxifene-Loaded Lipid Nanovesicles: A Journey to Select the Optimal Nanocarrier Formulation Through Characterization and Cytotoxic Analysis2025
  3. 3Design and Development of Optimised Nanostructured Polymeric Systems of Raloxifene For Improved Biopharmaceutical Application in Breast Cancer: A Review2025
  4. 4Targeted Delivery of Raloxifene via RGD-functionalized Chitosan Nanoparticle Selectively Attenuates Breast Tumor Growth2025
  5. 5Co‐Loaded Nanoparticles of Empagliflozin and Rutin for Pancreatitis Prevention and Anticancer Activity2025 · 2 citations