The synthesis of β-enamino esters from the thermal, catalyst-free ring opening of aminocyclopropenones

K. Hemming; Farideh Javid; Bimod Thapa; C. A. Lawson; Mark Soesanto

doi:10.1039/d5ob01290b

January 1, 2025Organic & Biomolecular ChemistryOpen Access

The synthesis of β-enamino esters from the thermal, catalyst-free ring opening of aminocyclopropenones

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Key Points

Aminocyclopropenones were found to undergo a previously unreported reaction, yielding β-enamino esters.
The reaction demonstrated both stereospecific and regiospecific characteristics in the synthesis of the desired products.
Catalyst-free conditions were employed during the thermal ring opening process of the aminocyclopropenones.
This method could enhance the development of amido-substituted pyrrolizidine natural products.

Implication

Novel synthesis reveals a stereospecific and regiospecific reaction in β-enamino esters, highlighting aminocyclopropenones' potential in natural product synthesis.

Abstract

In an attempt to react aminocyclopropenones with cyclic imines in order to synthesise amido-substituted pyrrolizidine natural products, we found that aminocyclopropenones undergo a previously unreported stereospecific and regiospecific catalyst-free, thermal...

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Cite This Study

Hemming et al. (2025) studied this question.

synapsesocial.com/papers/68c198be9b7b07f3a061a56a https://doi.org/10.1039/d5ob01290b

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The synthesis of β-enamino esters from the thermal, catalyst-free ring opening of aminocyclopropenones

Key Points

Implication

Abstract

Discussion

Cite This Study

The synthesis of β-enamino esters from the thermal, catalyst-free ring opening of aminocyclopropenones

Key Points

Implication

Abstract

Discussion

Cite This Study

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