Abstract Background All societies benefit from a healthy population, and access to affordable, quality, evidence‐based medical care can improve health, productivity, and prosperity for all. Two decades ago, experts and stakeholders met at the Institute of Medicine and called for a “new health system for the 21st century.” More recently, efforts have been made to achieve a Learning Health System (LHS). Still, reform efforts in the United States have only marginally succeeded in improving the situation despite innovation, technology, enormous economic resources, and one of the strongest medical research endeavors in the world. Objectives To bring together diverse stakeholders in healthcare, science, technology, business, government and patient advocacy, to envision what lies beyond the so‐called Learning Health System approach. Methods In December 2022, the SYNERGY Forum was hosted by the National Academy of Medicine, convened in Washington, DC. This envisioning exercise, the first in a planned series of such events, was proposed and organized by the global non‐profit Alliance for Clinical Research Excellence and Safety (ACRES). The two‐day exercise combined didactic lectures on systems thinking, focused working‐groups, and interactive discussion, to create a vision for an integrated Intelligent HealthScience System (IHSS). Results The participants proposed creation of a platform and an engine of People, Processes, Policy, and Technology to design and realize this vision through an effective hard and soft systems approach. Conclusions This report captures what the multi‐stakeholder collaboration recommends toward achieving such a System and a proposal for continuation of a SYNERGY Forum to further advance needed change and a design process.
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