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September 10, 2025Acta Biochimica Iranica

Evaluation of Leucomethylene Blue as a Protective Agent Against Acetaminophen-Induced Acute Lung Injury

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Authors

MEMajid EfatiSGSahar GhoflchiMashhad University of Medical SciencesKKKhatereh Kharazmi

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Implication

Treatment with leucomethylene blue reduced oxidative and inflammatory damage in rats with acetaminophen-induced lung injury.

Key Points

  • LMB significantly diminished oxidative and inflammatory damage caused by acetaminophen toxicity.
  • Total antioxidant capacity and glutathione reductase activity were restored after LMB treatment.
  • LMB curbed the overproduction of pro-inflammatory cytokines in lung tissue, reducing damage.
  • Histopathological analysis confirmed that LMB improved pulmonary lesions and inflammation.

Cite This Study

Efati et al. (2025) studied this question.

synapsesocial.com/papers/68c198cd9b7b07f3a061add3https://doi.org/10.18502/abi.v3i2.19488
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative Protective Effect of Alpha-Lipoic Acid and Melatonin Against Acetaminophen-Induced Liver Injury in Male Rats2025
  2. 2R-α-Lipoic Acid Attenuates Acetaminophen-Induced Acute Liver Injury by Reducing Oxidative Stress, Inflammation, and Mitochondrial Damage in Mice2026
  3. 3Evaluation of the effects of overdose Acetaminophen toxicity in rats: Ozone, which can be preferred as a complementary therapy2024
  4. 4The Consequence of Antioxidant Signaling Pathways on Acetaminophen Nephrotoxicity2024 · 1 citations
  5. 5Differential effects on acetaminophen-induced nephrotoxicity and liver injury following modulation of glutathione resynthesis2025 · 3 citations