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September 10, 2025Current Alzheimer Research

Role of GSK-3 Inhibition in Alzheimer’s Disease Therapy

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Authors

HAHala AlgazzawiJAJakleen AbujamaiAAAsim Muhammed Alshanberi

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Overview

Review highlights GSK-3's involvement in tau and beta-amyloid pathology in Alzheimer's Disease.

Key Points

  • GSK-3 is linked to cognitive decline in Alzheimer's disease due to its role in tau phosphorylation and amyloid production.
  • Overexpression of GSK-3 has been associated with neurofibrillary tangles and reduced cognitive function, emphasizing its significance in disease pathology.
  • The potential of GSK-3 inhibitors, particularly lithium, shows promise in alleviating tau hyperphosphorylation and cognitive impairment.
  • Recent research expands on how targeting GSK-3 can modify pathological processes in Alzheimer's disease, indicating a viable therapeutic strategy.

Cite This Study

Algazzawi et al. (2025) studied this question.

synapsesocial.com/papers/68c198cd9b7b07f3a061ae29https://doi.org/10.2174/0115672050400781250904082943
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The dual role of glycogen synthase kinase-3 beta (GSK3β) in neurodegenerative pathologies: interplay between autophagy and disease progression2025
  2. 2Targeting GSK3β with a Synthetic Small Molecule Rescues Neurotoxicity in a Cellular Model of Alzheimer’s Disease2026
  3. 3Biotechnological Perspectives on GSK-3β and Hyperprolactinemia: Implications for the Progression of Alzheimer’s Disease2026
  4. 4Regulation of Glycogen Synthase Kinase-3β by Phosphorylation and O-β-Linked N-Acetylglucosaminylation: Implications on Tau Protein Phosphorylation2024 · 17 citations
  5. 5Identification of Novel Scaffolds Against GSK-3β for Targeting Alzheimer’s Disease Through Molecular Modeling Techniques2025 · 2 citations