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October 21, 2025Frontiers in PharmacologyOpen Access

The dual role of glycogen synthase kinase-3 beta (GSK3β) in neurodegenerative pathologies: interplay between autophagy and disease progression

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Authors

HAHassan H. AlhassanKJKomal JaniyaniMSMalvi Surti

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Overview

Review reveals GSK3β's dual role in autophagy dysregulation and disease progression in neurodegenerative conditions.

Key Points

  • GSK3β is implicated in the progression of neurodegenerative diseases by affecting autophagy processes, leading to neuronal loss.
  • Evidence highlights that dysregulation of autophagy due to GSK3β impacts key proteins like Beclin-1 and LC3, worsening neurodegeneration.
  • Therapeutic targeting of GSK3β through inhibitors shows promise, with ongoing clinical trials assessing their effectiveness in neuroprotection.
  • Challenges such as off-target effects and complex pathways need addressing to improve GSK3β modulation for neurodegenerative disorders.

Cite This Study

Alhassan et al. (2025) studied this question.

synapsesocial.com/papers/68f74e597f21f73e19e5b331https://doi.org/10.3389/fphar.2025.1693805
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