Case analysis highlights the challenge of distinguishing tumor recurrence from capillary telangiectasia using 18 F-FET-PET and MRI.
This image highlights a diagnostic pitfall in a 65-year-old patient with recurrent glioblastoma. 18 F-FET-PET revealed 2 hotspots with focally enhanced uptake: local tumor recurrence (TBR max 2.3) on the left and another lesion in the right anterior cingulate gyrus (TBR max 1.8), suspicious for a distant tumor manifestation. However, multimodal MRI revealed a benign capillary telangiectasia in the anterior cingulate gyrus. While 18 F-FET-PET is highly sensitive for detecting tumor activity, vascular malformations may also exhibit moderate tracer uptake. Therefore, careful interpretation and comparison with multiple MRI sequences are essential.
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Polenz et al. (2025) studied this question.
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