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September 10, 2025JAMA Network OpenOpen Access

Sex-Related Measurement Bias in Autism Spectrum Disorder Symptoms in the Baby Siblings Research Consortium

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Authors

CBCatherine A. BurrowsSSSooyeon SungSZShuting Zheng

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Overview

Cohort study uncovers measurement bias in autism spectrum disorder symptoms by gender, suggesting improvement for earlier identification.

Key Points

  • Measurement bias was identified in autism spectrum disorder symptoms, with females rated less impaired compared to males.
  • In the high familial likelihood group, females showed fewer difficulties in eye contact and social communication traits.
  • Cohort study utilized longitudinal data from the Baby Siblings Research Consortium to analyze symptom differences by sex.
  • Findings suggest that diagnostic criteria should consider sex differences to enhance early identification of ASD in females.

Cite This Study

Burrows et al. (2025) studied this question.

synapsesocial.com/papers/68c19f7f54b1d3bfb60daa88https://doi.org/10.1001/jamanetworkopen.2025.25887
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Item-Level Sex Differences in Autism Spectrum Disorder Measures: A MIMIC Model Analysis of ADOS-2 and ADI-R in a Referred Pediatric Sample2026
  2. 2The Under-Identification of Autism in Females: A Review and Analysis of Sex-Based Scoring Differences Observed in Autism Diagnostic Observation Schedule (ADOS) Module 32026
  3. 3Characterizing individual differences in children and adolescents with autism spectrum disorder: a descriptive study2024 · 11 citations
  4. 4Diagnosing ASD in Children Aged 6–18: Gender Differences and the Diagnostic Process2026 · 2 citations
  5. 5Measurement‐Dependent Sex‐Based Differences in Autistic Traits: Comparing Self‐Report, Informant‐Report, and Clinician Observation in Adults With Autism Spectrum Disorder2026