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September 10, 2025Biomedical ReportsOpen Access

Anti‑neuroinflammatory potential of porcine liver decomposition products in improving behavioral abnormalities: Effects on formalin‑ and LPS‑induced inflammation

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Authors

ISIkuya SatoTMTomoji MaedaSKS Katsuyama

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Overview

Observational analysis showed anti-inflammatory effects of porcine liver decomposition product in LPS-induced inflammation, suggesting implications for neuroprotection.

Key Points

  • PLDP reduced inflammatory behavior in mice, indicating its potential therapeutic role in neuroinflammation.
  • Mice treated with PLDP demonstrated improved locomotor activity and reduced proinflammatory cytokine levels after LPS exposure.
  • Flow cytometry results indicated PLDP promotes M2 macrophage phenotype, contributing to anti-inflammatory effects.
  • Oral administration of PLDP for five days showed significant reductions in inflammation-related behaviors and cytokine production.

Cite This Study

Sato et al. (2025) studied this question.

synapsesocial.com/papers/68c19f7f54b1d3bfb60dac39https://doi.org/10.3892/br.2025.2032
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