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September 10, 2025DiagnosticsOpen Access

Clonal Hematopoiesis of Intermediate Potential in Atrial Fibrillation: A Critical View of Current Knowledge as a Springboard for Future Research

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This review explores the impact of CHIP mutations on atrial fibrillation severity and cardiovascular risk, highlighting potential mechanisms.

Clonal hematopoiesis of intermediate potential is associated with a two-fold increase in cardiovascular risk, emphasizing its clinical importance.
Patients with atrial fibrillation show a higher incidence of CHIP mutations like TET2 and DNMT3A compared to healthy controls.
The presence of TET2 and ASXL1 mutations is correlated with increased interleukin-6 levels, which are linked to cardiac remodeling.
Research aims to clarify how CHIP mutations contribute to atrial fibrillation severity and the potential for targeted interventions.

Chatzikalil et al. (2025) studied this question.

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September 10, 2025DiagnosticsOpen Access

View Full Paper

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Authors

This review explores the impact of CHIP mutations on atrial fibrillation severity and cardiovascular risk, highlighting potential mechanisms.

Clonal hematopoiesis of intermediate potential is associated with a two-fold increase in cardiovascular risk, emphasizing its clinical importance.
Patients with atrial fibrillation show a higher incidence of CHIP mutations like TET2 and DNMT3A compared to healthy controls.
The presence of TET2 and ASXL1 mutations is correlated with increased interleukin-6 levels, which are linked to cardiac remodeling.
Research aims to clarify how CHIP mutations contribute to atrial fibrillation severity and the potential for targeted interventions.

Chatzikalil et al. (2025) studied this question.

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