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September 10, 2025Urological ScienceOpen Access

Validation of neutrophil-to-lymphocyte ratio for prognosis and treatment selection in muscle-invasive bladder cancer: A single-institutional longitudinal study

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Authors

STSheng‐Feng TsaiTCTing‐Yi ChiangWTWen‐Hsin Tseng

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Overview

Retrospective cohort study shows neutrophil-to-lymphocyte ratio predicts outcomes in muscle-invasive bladder cancer, guiding treatment options.

Key Points

  • High neutrophil-to-lymphocyte ratio is linked to shorter time to recurrence and increased mortality rates.
  • Patients with a low neutrophil-to-lymphocyte ratio undergoing radical cystectomy have better disease-free survival.
  • Multivariate analysis indicates advanced tumor staging as a significant predictor of recurrence and death.
  • Elevated neutrophil-to-lymphocyte ratio can help stratify muscle-invasive bladder cancer patients for treatment decisions.

Cite This Study

Tsai et al. (2025) studied this question.

synapsesocial.com/papers/68c19fa854b1d3bfb60db839https://doi.org/10.1097/us9.0000000000000095
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic Significance of Pre-Treatment Serum Markers in Muscle-Invasive Bladder Cancer Under Tri-Modality Therapy2025
  2. 2Prognostic Significance of Lymph Node Ratio for Overall Survival in Patients with Lymph Node-Positive Bladder Cancer Post-Radical Cystectomy and Chemotherapy: A Multicenter Cohort Analysis2026 · 1 citations
  3. 3The prognostic role of preoperative neutrophil-to-lymphocyte ratio in upper tract urothelial carcinoma2024 · 2 citations
  4. 4Change in the neutrophil‐lymphocyte ratio may predict early recurrence in operated bladder cancer2024 · 2 citations
  5. 5Prognostic Value of Postneoadjuvant Chemotherapy Neutrophil-to-Lymphocyte Ratio in Patients undergoing Radical Cystectomy2024