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July 22, 2025

Prognostic Significance of Pre-Treatment Serum Markers in Muscle-Invasive Bladder Cancer Under Tri-Modality Therapy

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Authors

YCYu-Chen ChangDTDin‐Li TsanWYWing‐Keen Yap

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Overview

Analysis shows lymphocyte ratios influence tumor control and survival in muscle-invasive bladder cancer, suggesting targeted therapies could optimize outcomes.

Key Points

  • Lower neutrophil-to-lymphocyte ratio values correlate with improved prognosis in muscle-invasive bladder cancer.
  • Higher lymphocyte-to-monocyte ratio values are associated with better locoregional control and survival outcomes.
  • Dose escalation in radiotherapy improves tumor control for patients with lower lymphocyte-to-monocyte ratio values.
  • Finding optimal lymphocyte ratios may guide treatment strategies in improving overall survival for bladder cancer patients.

Cite This Study

Chang et al. (2025) studied this question.

synapsesocial.com/papers/689a061be6551bb0af8cd7f4https://doi.org/10.21203/rs.3.rs-7042522/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Validation of neutrophil-to-lymphocyte ratio for prognosis and treatment selection in muscle-invasive bladder cancer: A single-institutional longitudinal study2025
  2. 2Prognostic Significance of Lymph Node Ratio for Overall Survival in Patients with Lymph Node-Positive Bladder Cancer Post-Radical Cystectomy and Chemotherapy: A Multicenter Cohort Analysis2026 · 1 citations
  3. 3Prognostic role of the neutrophil/lymphocyte ratio in high‐risk BCG‐naïve non‐muscle‐invasive bladder cancer treated with intravesical gemcitabine/docetaxel2024 · 10 citations
  4. 4Prognostic Significance of Peripheral Blood Neutrophil‐To‐Lymphocyte Ratio ( <scp>NLR</scp> ), Monocyte‐To‐Lymphocyte Ratio ( <scp>MLR</scp> ), and Platelet‐To‐Lymphocyte Ratio ( <scp>PLR</scp> ) in Patients With Multiple Myeloma: A Retrospective Cohort Study2026
  5. 5Preoperative Platelet-to-Lymphocyte Ratio as a Predictor of Recurrence and Recurrence-Free Survival in Non-Muscle-Invasive Bladder Cancer Across Different Intravesical Therapies2026