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August 20, 2026Journal of Clinical Laboratory AnalysisOpen Access

Prognostic Significance of Peripheral Blood Neutrophil‐To‐Lymphocyte Ratio ( NLR ), Monocyte‐To‐Lymphocyte Ratio ( MLR ), and Platelet‐To‐Lymphocyte Ratio ( PLR ) in Patients With Multiple Myeloma: A Retrospective Cohort Study

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Authors

LZLihong ZhangBMBing MaJZJingyu Zhang

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Overview

Retrospective cohort study reveals elevated inflammatory ratios predict poor survival in multiple myeloma, highlighting simple markers for risk stratification.

Key Points

  • To evaluate whether systemic inflammatory markers—neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR)—improve prognostic assessment and identify high-risk patients with newly diagnosed multiple myeloma.
  • Conducted a single-center retrospective analysis of N=268 newly diagnosed multiple myeloma patients treated with novel agents between January 2019 and December 2023.
  • Determined optimal biomarker cut-offs using receiver operating characteristic (ROC) curves and evaluated progression-free survival (PFS) and overall survival (OS) with Kaplan-Meier and multivariate Cox regression analyses.
  • Optimal cut-off values were identified as 2.85 for NLR, 0.34 for MLR, and 142.5 for PLR; elevated NLR and MLR significantly correlated with stage III R-ISS, anemia, and elevated beta-2 microglobulin (p < 0.01).
  • Multivariate Cox regression adjusted for cytogenetic risk and post-induction autologous stem cell transplantation confirmed high NLR (HR = 1.84, 95% CI: 1.22–2.78, p = 0.004) and high MLR (HR = 1.65, 95% CI: 1.10–2.48, p = 0.015) as independent prognostic factors, while PLR was not significant.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a86b5eb8a91293e6a1cd7f7https://doi.org/10.1002/jcla.70308
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1“Prognostic Significance of Neutrophil‐to‐Lymphocyte, Platelet‐to‐Lymphocyte, and Monocyte‐to‐Lymphocyte Ratios in Myeloid Neoplasms: A Systematic Review”2026
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  4. 4Prognostic Value of the Neutrophil-to-lymphocyte Ratio, Platelet-to- lymphocyte Ratio and Monocyte-to-lymphocyte Ratio in Melanoma Patients: A Cohort Study2024 · 4 citations
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