Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 29, 2026Health Science ReportsOpen Access

“Prognostic Significance of Neutrophil‐to‐Lymphocyte, Platelet‐to‐Lymphocyte, and Monocyte‐to‐Lymphocyte Ratios in Myeloid Neoplasms: A Systematic Review”

View Full Paper
Ask AI
Bookmark
Share

Authors

MDMahsa DabirAAAli AbdolbaghaeiFZFatemeh Zoghi

Discussion

Loading...

Member takes

Overview

Systematic review shows that elevated inflammatory blood ratios predict worse survival in myeloid neoplasms, highlighting their potential as accessible prognostic biomarkers.

Key Points

  • To evaluate the prognostic and diagnostic utility of neutrophil-to-lymphocyte, platelet-to-lymphocyte, and monocyte-to-lymphocyte ratios in myelodysplastic syndromes and acute myeloid leukemia.
  • Systematic search of PubMed, Web of Science, and Scopus from inception through June 2026 for studies assessing NLR, PLR, or MLR in MDS or AML.
  • Included 13 studies comprising 2,847 patients, converting lymphocyte-to-monocyte ratio values to MLR (MLR = 1/LMR) and synthesizing data narratively due to heterogeneity.
  • Elevated NLR, PLR, and MLR were consistently associated with shorter overall survival, with NLR demonstrating independent prognostic value in AML and higher-risk MDS (HR: 1.05–2.136).
  • MLR yielded the most consistent prognostic value across cutoffs of 0.20–0.67, whereas PLR demonstrated context-dependent utility across variable cutoffs ranging from 22.14 to 213.2.
  • A single study reported diagnostic accuracy, showing excellent discrimination for NLR (AUC = 0.9169) and good discrimination for PLR (AUC = 0.8312).

Cite This Study

Dabir et al. (2026) studied this question.

synapsesocial.com/papers/6a9299bb8e5d7d1fc0c11cf5https://doi.org/10.1002/hsr2.73049
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic Significance of Peripheral Blood Neutrophil‐To‐Lymphocyte Ratio ( <scp>NLR</scp> ), Monocyte‐To‐Lymphocyte Ratio ( <scp>MLR</scp> ), and Platelet‐To‐Lymphocyte Ratio ( <scp>PLR</scp> ) in Patients With Multiple Myeloma: A Retrospective Cohort Study2026
  2. 2Prognostic Impact of Lymphocyte to Monocyte Ratio in Patients with Myelodysplastic Neoplasms/Syndromes2025
  3. 3Prognostic value of hematological ratios in sepsis: A prospective observational study of neutrophil-to-lymphocyte, platelet-to-lymphocyte, and monocyte-to-lymphocyte ratios2026 · 1 citations
  4. 4The Prognostic Role of Different Blood Cell Count-to-Lymphocyte Ratios in Patients with Lung Cancer at Diagnosis2025 · 3 citations
  5. 5The Evaluation of Diagnostic, Prognostic, and Predictive Role of Hematologic Inflammatory Indices <scp>NLR</scp> , <scp>PLR</scp> , and <scp>LMR</scp> in Common Solid Tumors2025 · 11 citations