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September 10, 2025HematologyOpen Access

Association between lymphocyte-associated ratios, C-reactive protein and prognostic value in myelodysplastic syndromes

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Authors

HCHong-Kai CaiLJLin JiangJGJianbin Gong

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Overview

Observational analysis shows poor prognosis linked with C-reactive protein and lymphocyte ratios in MDS patients, suggesting relevance for clinical outcomes.

Key Points

  • High levels of C-reactive protein indicate a worse overall survival in MDS patients, with a median of only 28 months.
  • Favorable outcomes correlated with lymphocyte-associated ratios, as significant differences were noted in survival rates.
  • The study utilized the Kaplan-Meier method for survival analysis and X-tile software to determine cutoff points for inflammatory markers.
  • Elevated markers were found to be independent predictors of poor prognosis in newly diagnosed patients with myelodysplastic syndromes.

Cite This Study

Cai et al. (2025) studied this question.

synapsesocial.com/papers/68c19fa854b1d3bfb60db7c7https://doi.org/10.1080/16078454.2025.2538950
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1“Prognostic Significance of Neutrophil‐to‐Lymphocyte, Platelet‐to‐Lymphocyte, and Monocyte‐to‐Lymphocyte Ratios in Myeloid Neoplasms: A Systematic Review”2026
  2. 2Improving MDS Risk Assessment: The Role of Monocytopenia and Lymphocytopenia Beyond IPSS-R2025 · 1 citations
  3. 3Prognostic Impact of Lymphocyte to Monocyte Ratio in Patients with Myelodysplastic Neoplasms/Syndromes2025
  4. 4From chaos to clarity? decoding the inflammatory profiles in lower-risk MDS2025
  5. 5Prognostic Significance of Peripheral Blood Neutrophil‐To‐Lymphocyte Ratio ( <scp>NLR</scp> ), Monocyte‐To‐Lymphocyte Ratio ( <scp>MLR</scp> ), and Platelet‐To‐Lymphocyte Ratio ( <scp>PLR</scp> ) in Patients With Multiple Myeloma: A Retrospective Cohort Study2026