The protocol demonstrates regiodivergent outcomes in alcohol synthesis, suggesting new pathways for β/γ-substituted compounds.
Herein, we describe a regiodivergent interrupted chain-walking of unsaturated aliphatic alcohols. The method leverages the potential of traceless groups to forge C(sp3)-C(sp3) and C(sp3)-nitrogen bonds at distal methylene sp3 C-H sites, with site selectivity dictated by a judicious choice of the ligand. The protocol is distinguished by its broad applicability, offering unconventional disconnections to access β/γ-substituted aliphatic alcohols that are difficult to reach otherwise.
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Wang et al. (2025) studied this question.
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