This research demonstrates selectivity control in thiolation and difluoroalkylation of alkynes, suggesting new synthetic pathways.
A visible-light-induced three-component regioselective thiolation-difluoroalkylation of alkynes is reported. This mild reaction system is compatible with a wide range of unactivated alkynes, trifluoromethylarenes, and thiols, enabling the selective formation of gem-difluoroalkyl thioethers with acetylene substituents distal to the sulfur atom. This regioselectivity is achieved through an accurate reaction cascade of sequential thiolation and difluoroalkylation.
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Zhu et al. (2025) studied this question.
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