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September 10, 2025Annals of JointOpen Access

Genome-wide association assessment between immune cells and osteoarthritis: a bidirectional Mendelian randomization study

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Authors

JZJ ZhengYSYujun SunWLWenzhou Liu

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Overview

Bidirectional Mendelian randomization reveals immune cell traits significantly influence osteoarthritis, suggesting new treatment avenues.

Key Points

  • Thirteen immune cell traits showed significant causal relationships with osteoarthritis.
  • The strongest effects on OA were linked to specific monocyte phenotypes with OR values indicating notable risk levels.
  • Bidirectional Mendelian randomization methodology utilized GWAS data to assert causal connections between immune cells and OA.
  • Findings support the potential for novel immunological treatments targeting immune cell phenotypes in osteoarthritis.

Cite This Study

Zheng et al. (2025) studied this question.

synapsesocial.com/papers/68c1a12754b1d3bfb60dbedchttps://doi.org/10.21037/aoj-24-60
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  5. 5Complex causal association between immune cells and psoriatic arthritis: A bidirectional Mendelian randomization study2025 · 1 citations