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May 24, 2026MedicineOpen Access

Focus on CCL19: A Mendelian randomization study on genetic evidence of immune cells influencing osteoarthritis severity via inflammatory proteins

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Authors

SCShuai ChenKunming Medical UniversityYGYudong GanKunming Medical UniversityFWFang WangThe Wistar Institute

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Overview

Randomized trial explores immune cells' impact on osteoarthritis severity, suggesting CCL19 as a therapeutic target.

Key Points

  • This study aimed to determine the causal effects of immune cells on osteoarthritis (OA) severity, focusing on the role of CCL19.
  • Employs Mendelian randomization analysis using public genome-wide association study datasets.
  • Analyzes genetic data for 471 immune cell types, 91 inflammatory proteins, and OA phenotypes.
  • Utilizes inverse variance weighted method and MR-Egger regression for analyses.
  • Myeloid cell activation showed a positive correlation with OA risk (OR = 1.014–1.049, P < .05).
  • Regulatory T cell expression demonstrated a protective effect against OA (OR = 0.921–0.958, P < .05).
  • CCL19 exhibited a protective effect on OA risk (OR = 0.876–0.924, P < .001) while mediating risk from immune cells.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a1296d548a0ea1665673f48https://doi.org/10.1097/md.0000000000048948
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Also Consider

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  5. 5The Causal Effects Between Circulating Inflammatory Proteins and Osteoarthritis: A Mendelian Randomization and Transcriptomic Analysis2025 · 1 citations