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September 10, 2025Deleted JournalOpen Access

Microfluidic nano-plasmonic imaging platform for purification- and label-free single small extracellular vesicle characterization

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Authors

ODOmid Mohsen DaraeiASAvinash Kumar SinghUniversity of HoustonSMSaswat MohapatraUniversity of Houston

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Overview

This platform enables label-free imaging and purification-free analysis of small extracellular vesicles in plasma, suggesting efficient biomarker detection.

Key Points

  • The platform allows for effective and rapid single small extracellular vesicle characterization without purification.
  • Using only 20 µL of plasma, the analysis can be completed in under 60 minutes.
  • The automated system improves precision in controlling flow rates and directions during analysis.
  • By integrating plasmonic imaging, the platform enhances the detection of circulating sEVs in complex biological samples.

Cite This Study

Daraei et al. (2025) studied this question.

synapsesocial.com/papers/68c1a12d54b1d3bfb60dc3behttps://doi.org/10.1038/s44328-025-00047-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Isolation and Purification-Free Digital Single-Small Extracellular Vesicle Biosensing with Scalable Plasmonic Arrays2026
  2. 2Plasmonic nano-aperture label-free imaging of single small extracellular vesicles for cancer detection2024 · 4 citations
  3. 3A 3D Nanofiltration Array for Direct Plasma EV Purification with Label-Free SERS Detection toward Accurate Clinical Breast Cancer Staging2025 · 11 citations
  4. 4Direct isolation of small extracellular vesicles from human blood using viscoelastic microfluidics2023 · 88 citations
  5. 5Optimizing plasma-derived small extracellular vesicle purification to enhance downstream applications2026