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April 23, 2026ACS SensorsOpen Access

Wash-Free Digital Detection of Tumor Extracellular Vesicles via Plasmonic Droplet Microfluidics

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Authors

NJNa Kyung JungMKMamata KarmacharyaHCHyunMin Choi

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Overview

This assay detects tumor-derived extracellular vesicles in plasma, suggesting a breakthrough in cancer diagnostics.

Key Points

  • To develop a wash-free digital plasmonic assay for the detection of tumor-derived extracellular vesicles.
  • Developed PlasDroplex assay using droplet-confined binding of EVs with antibody-functionalized gold nanoparticles.
  • Coencapsulated plasma and nanoparticles within picoliter droplets to facilitate detection.
  • Conducted optical readout to differentiate between 'On' and 'Off' droplets based on target binding.
  • Detection limits ranged from 2500 to 6700 EVs/mL with a high reproducibility rate.
  • In clinical samples, achieved AUCs of 0.926 and 0.932 for PSA and PSMA positivity in prostate cancer.
  • PD-L1 EVs exhibited an exceptional AUC of 0.998 for lung cancer detection.

Cite This Study

Jung et al. (2026) studied this question.

synapsesocial.com/papers/69e9baeb85696592c86eccddhttps://doi.org/10.1021/acssensors.5c03705
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