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September 10, 2025Advanced ScienceOpen Access

Ultrasound‐Mediated Biotransfection of Engineered Bone Marrow Mesenchymal Stem Cells in Treated Bone Defects through Intracellular Cavitation

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Authors

ZXZhili XuHXHuijuan XinYWYu Wang

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Overview

Research demonstrates improved gene transfection in mesenchymal stem cells for bone defects, suggesting enhanced treatment efficacy.

Key Points

  • Intracellular cavitation significantly boosts plasmid nuclear translocation and gene transfection efficiency.
  • The transfection efficiency increased by 131.6% compared to conventional methods, enhancing treatment outcomes.
  • Engineered bone marrow mesenchymal stem cells showed improved osteogenic differentiation and expression of BMP2.
  • This approach offers a more secure and efficient method for stem cell gene therapy in bone defect repair.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68c1a12d54b1d3bfb60dc3c0https://doi.org/10.1002/advs.202503196
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